CAS 1006381-03-8 | Orforglipron intermediate Manufacturer & Supplier in China

Product Overview

(4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide (CAS 1006381-03-8), also widely recognized as a critical chiral intermediate for the synthesis of Orforglipron, represents a sophisticated cyclic sulfate ester used in advanced medicinal chemistry. Within the Pharmaceutical Intermediates and fine chemical manufacturing sectors, this specific (4R) enantiomer is essential for constructing the complex molecular framework of next-generation non-peptide GLP-1 receptor agonists. The precision of the chiral center in this molecule is paramount, as it directly influences the stereochemical outcome of the final active pharmaceutical ingredient. As a leading manufacturer of (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8 based in China, Conscientia Industrial utilizes high-vacuum distillation and asymmetric catalytic pathways to ensure the highest enantiomeric excess and chemical purity. Our technical team focuses on stabilizing this reactive intermediate to ensure it meets the rigorous quality benchmarks required for multi-step drug synthesis and large-scale industrial applications. Our product is designed to provide consistent performance in nucleophilic ring-opening reactions, facilitating the efficient production of Orforglipron with minimal byproduct formation.

Technical Specifications

• Product Name: (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide

• CAS Number: 1006381-03-8

• Category: Pharmaceutical Intermediates

• Quality Standard: In-House Specification

• Purity (GC/HPLC): ≥98.0%

• Enantiomeric Excess (ee): ≥99%

• Molecular Formula: C3H6O4S

• Molecular Weight: 138.14

• Appearance: Colorless to light yellow liquid or low melting solid

• Density: 1.45±0.1 g/cm3

• Application: Orforglipron intermediate

• Brand: Conscientia Industrial

• Country of Origin: China

• Availability: In Stock

• Pricing: Competitive price based on order quantity

• Currency: USD

• Molecular Structure:

Why Partner with Conscientia Industrial

• Technical Quality Control: Our manufacturing process follows rigorous analytical protocols to ensure high-grade batch-to-batch consistency for (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8.

• Advanced Analytical Verification: Every batch is validated through Chiral GC/HPLC and NMR spectroscopy to confirm the (4R) configuration and ensure the absence of critical impurities.

• Full Technical Documentation: We provide comprehensive support, including Certificate of Analysis (COA), MSDS, and Method of Analysis (MOA) for (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8.

• Scalable Production Capacity: Our China facility is equipped to support projects ranging from pilot-scale laboratory research to multi-ton bulk industrial supply for GLP-1 intermediate programs.

• Direct Source Advantage: As a primary manufacturer, we provide (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8 with efficient lead times and direct factory technical support for process optimization.

Packaging & Storage

• Standard Packaging: 1kg, 5kg, or 25kg specialized fluorinated bottles or drums with inert gas padding to prevent hydrolysis.

• Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from moisture and strong oxidizing agents.

• Shelf Life: 24 months when stored under the recommended conditions in original unopened packaging.

• Safety Handling: This material is a technical-grade chemical intermediate intended for industrial production and laboratory research use only. Wear appropriate protective equipment during handling.

Our logistics team ensures secure distribution of (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8 via global courier, air freight, and sea freight with temperature-controlled options if required.

Request a Quote & COA for (4R)-Methyl-[1,3,2]dioxathiolane 2,2-dioxide CAS 1006381-03-8 Today.